β-Nicotinamide mononucleotide: a novel broad-spectrum CRISPR inhibitor
Tong Wei, Wei Shen, Wenjun Li, Yingjie Song, Yunzhi Fa, Jing An, Yansong Sun, Hao Li
This paper identifies β-nicotinamide mononucleotide (NMN) as a naturally occurring broad-spectrum CRISPR inhibitor that targets multiple Cas proteins, reducing off-target effects and improving safety in genome editing.
bioRxiv · Nov 22, 2025 · PreprintGenetics