Inference and validation of causal genetic interactions in aging human fibroblasts
Madison S. Krieger, Denitsa Milanova, David Alan Thompson, Nadire R. Cochran, Tongyao Wang, Barsha Pokharel, Robert P Ford, Andrei H Gheorghe, William Gilpin, Yoav Freund, George Sugihara, George M. Church
This paper uses convergent cross mapping to infer causal genetic interactions from cross-sectional transcriptomic data of aging human fibroblasts and validates these interactions experimentally.
bioRxiv · Oct 23, 2026 · PreprintSystems Biology