Denitsa Milanova

This paper uses convergent cross mapping to infer causal genetic interactions from cross-sectional transcriptomic data of aging human fibroblasts and validates these interactions experimentally.

The paper identifies tumor-reactive T cells by focusing on productive T-cell engagement with tumor cells, showing that such interactions enrich for neoantigen-reactive clonotypes with progenitor-like states.

The paper identifies and validates two novel human genomic sites for safe and predictable gene expression in therapeutic applications.

The paper introduces BOLORAMIS, a RT-free method for spatially-resolved, targeted in-situ RNA detection, and demonstrates its use on human iPSCs to identify spatial localization and expression heterogeneity.