Systematic computational assessment of atrial function impairment due to fibrotic remodeling in electromechanical properties
Åshild Telle, Ahmad Kassar, Nadia Chamoun, Romanos Haykal, Alejandro Gonzalo, Tori Hensley, Yaacoub Chahine, Óscar Flores, Juan C. del Álamo, NAZEM W. AKOUM, Christoph M. Augustin, Patrick M. Boyle
This study uses a computational model to assess how fibrosis-related changes in electrophysiological and mechanical properties affect left atrial function, finding that reduced L-type calcium current most impairs function while reduced inward rectifier current improves it.
PLoS Computational Biology · Dec 5, 2025Peer-reviewedSystems Biology