Author

NAZEM W. AKOUM

University of WashingtonORCID 0000-0002-2001-6806Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 3 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:imaging· 3 Approach:experimental assay· 2 Organism:human· 2 Research Focus:differential expression· 1 Assay:electronic health records· 1 Research Focus:host-pathogen & immune response· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Alejandro GonzaloiD· 4 shared Åshild TelleiD· 4 shared Christoph M. AugustiniD· 4 shared Juan C. del ÁlamoiD· 4 shared Óscar FloresiD· 4 shared Patrick M. BoyleiD· 4 shared Ahmad KassariD· 3 shared Eduardo DurániD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBioengineering

Alejandro GonzaloORCID

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Author profile →

4 papers

Recent·Most cited

Fibrosis burden and spatial pattern affect left atrial appendage stasis in multi-beat multi-physics simulations

Yvonne Stöcker, Christoph M. Augustin, Manuel Guerrero‐Hurtado, Óscar Flores, Alejandro Gonzalo, Åshild Telle, Patrick M. Boyle, NAZEM W. AKOUM, Juan C. del Álamo, Manuel García‐Villalba

This study investigates how fibrosis burden and spatial distribution affect left atrial appendage hemodynamics using multi-physics simulations.

bioRxiv · Oct 10, 2026 · PreprintBioengineering

Systematic computational assessment of atrial function impairment due to fibrotic remodeling in electromechanical properties

Åshild Telle, Ahmad Kassar, Nadia Chamoun, Romanos Haykal, Alejandro Gonzalo, Tori Hensley, Yaacoub Chahine, Óscar Flores, Juan C. del Álamo, NAZEM W. AKOUM, Christoph M. Augustin, Patrick M. Boyle

This study uses a computational model to assess how fibrosis-related changes in electrophysiological and mechanical properties affect left atrial function, finding that reduced L-type calcium current most impairs function while reduced inward rectifier current improves it.

PLoS Computational Biology · Dec 5, 2025Peer-reviewedSystems Biology

Effect of Wall Motion Sampling on CFD-Derived Left Atrial Flow Metrics

Yvonne Stöcker, Manuel Guerrero-Hurtado, Eduardo Durán, Alejandro Gonzalo, Zorica Ristić, Åshild Telle, Ahmad Kassar, Romanos Haykal, NAZEM W. AKOUM, Patrick M. Boyle, Óscar Flores, Christoph M. Augustin, Juan C. del Álamo, Manuel García‐Villalba

This study evaluates how different temporal resolutions affect CFD-derived left atrial flow metrics, finding that higher frame rates improve accuracy while lower rates preserve patient ranking.

bioRxiv · Oct 24, 2025 · PreprintBioengineering

Multi-physics simulations reveal hemodynamic impacts of patient-derived fibrosis-related changes in left atrial tissue mechanics

Alejandro Gonzalo, Christoph M. Augustin, Savannah Bifulco, Åshild Telle, Yaacoub Chahine, Ahmad Kassar, Manuel Guerrero‐Hurtado, Eduardo Durán, Pablo Martínez‐Legazpi, Óscar Flores, Javier Bermejo, Gernot Plank, NAZEM W. AKOUM, Patrick M. Boyle, Juan C. del Álamo

This paper uses multi-physics simulations to show how fibrosis in left atrial tissue affects hemodynamics and increases stroke risk by altering flow patterns and reducing emptying fractions.

The Journal of Physiology · Nov 8, 2024Peer-reviewedBioengineering