Juan C. del Álamo

Three-Dimensional Fluid-Structure Interaction Reveals Trade-offs Among Oxygen Delivery, Shear, and Washout in Pediatric Roller-Pump Cardiopulmonary Bypass

This study uses a 3D fluid-structure interaction model to show that pediatric roller-pump settings with similar oxygen delivery can result in different shear and washout environments, suggesting the need for joint evaluation of these metrics.

Fibrosis burden and spatial pattern affect left atrial appendage stasis in multi-beat multi-physics simulations

This study investigates how fibrosis burden and spatial distribution affect left atrial appendage hemodynamics using multi-physics simulations.

Joint Vector Flow Mapping and Segmentation: Ill-Posedness,Differentiable Bayesian Inference, and Synthetic Vortex-FlowBenchmarks

This paper introduces Bayesian VFM (B-VFM) to address ill-posedness in vector flow mapping by jointly inferring velocity fields, segmentation masks, and uncertainties using Bayesian inference.

Left atrial flow and thrombosis risk from 4D CT contrast dynamics by physics-informed neural network and indicator dilution theory

This paper develops two methods to estimate left atrial blood residence time from 4D CT contrast data, showing that indicator dilution theory provides faster, more accurate results than a physics-informed neural network.

Systematic computational assessment of atrial function impairment due to fibrotic remodeling in electromechanical properties

This study uses a computational model to assess how fibrosis-related changes in electrophysiological and mechanical properties affect left atrial function, finding that reduced L-type calcium current most impairs function while reduced inward rectifier current improves it.

Effect of Wall Motion Sampling on CFD-Derived Left Atrial Flow Metrics

This study evaluates how different temporal resolutions affect CFD-derived left atrial flow metrics, finding that higher frame rates improve accuracy while lower rates preserve patient ranking.

Flow transport and not ejection fraction determines left ventricular stasis in patients with impaired systolic function

The paper develops queue models to assess left ventricular blood transit and shows that flow transport, not ejection fraction, determines stasis in patients with impaired systolic function.

Uncertainty-Aware Traction Force Microscopy

This paper introduces an uncertainty-aware Traction Force Microscopy technique that adapts regularization based on image quality and quantifies uncertainty in traction stress recovery.

Hemodynamics Affects Factor XI/XII Anticoagulation Efficacy in Patient-Specific Left Atrial Models

This study simulates blood flow and coagulation in patient-specific left atrium models to assess how hemodynamics affect the efficacy of factor XI/XII inhibitors in preventing thrombosis.

Multi-physics simulations reveal hemodynamic impacts of patient-derived fibrosis-related changes in left atrial tissue mechanics

This paper uses multi-physics simulations to show how fibrosis in left atrial tissue affects hemodynamics and increases stroke risk by altering flow patterns and reducing emptying fractions.

Neutrophils exhibit distinct migration phenotypes that are regulated by transendothelial migration

This study identifies two distinct neutrophil migration phenotypes regulated by transendothelial migration, with GRK2 signaling influencing the shift between them.

Super-resolution Left Ventricular Flow and Pressure Mapping by Navier-Stokes-Informed Neural Networks

This paper introduces AI-VFM, a physics-informed neural network method for super-resolution left ventricular flow and pressure mapping from echocardiographic data.

Kinematic analysis of cell lineage reveals coherent and robust mechanical deformation patterns in zebrafish gastrulation

The paper analyzes cell lineage data to reveal mechanical deformation patterns in zebrafish gastrulation, showing coherent and robust biomechanical behavior.