Christoph M. Augustin

This study investigates how fibrosis burden and spatial distribution affect left atrial appendage hemodynamics using multi-physics simulations.

The paper benchmarks global sensitivity analysis of whole-heart electromechanical models across five healthy subjects, finding haemodynamic parameters dominate cardiac function despite anatomical variation.

This study uses a computational model to assess how fibrosis-related changes in electrophysiological and mechanical properties affect left atrial function, finding that reduced L-type calcium current most impairs function while reduced inward rectifier current improves it.

This study evaluates how different temporal resolutions affect CFD-derived left atrial flow metrics, finding that higher frame rates improve accuracy while lower rates preserve patient ranking.

This paper uses multi-physics simulations to show how fibrosis in left atrial tissue affects hemodynamics and increases stroke risk by altering flow patterns and reducing emptying fractions.

The paper introduces openCARP, an open-source simulation environment for cardiac electrophysiology, and describes its capabilities and potential to improve reproducibility and standardization in the field.