Protective and pathogenic antibody responses from a primate Shigella outbreak inform vaccine design
Robert M. Gallant, Paul Savarino, Sophia Pulido, Morgan S. A. Gilman, Ti Lu, Jennifer M. Hayes, Nicholas L. Xerri, Torrey Williams, Mark A. Ochoa, Zackary K. Dietz, Eric J. Peterson, Timothy A. Scott, Faye A. Hartmann, Stephen G. Baker, Robert W. Kaminski, , Hayden R. Schmidt
The paper isolates antibodies from a Shigella outbreak in non-human primates, showing some target O-antigen and T3SS proteins, with some antibodies enhancing virulence.
bioRxiv · Dec 19, 2025 · PreprintImmunology