Hayden R. Schmidt

This paper demonstrates the feasibility of expressing monoclonal IgG and IgA antibodies in non-human primates using mRNA-LNPs, showing both isotypes retain HIV-neutralizing function and native-like glycosylation.

The paper isolates antibodies from a Shigella outbreak in non-human primates, showing some target O-antigen and T3SS proteins, with some antibodies enhancing virulence.

This paper improves the affinity and potency of a monoclonal antibody against Shigella flexneri 3a O-antigen using phage display and whole-cell panning, showing enhanced antibacterial activity and broader serotype recognition.

The paper investigates the evolution of olfactory receptor specificity in Drosophila by analyzing extant and ancestral IR receptors, identifying a common hotspot that influences ligand binding and functional transitions.