Most of transcriptional alterations in glioma result from DNA-methylation independent mechanisms
Franck Court, Elisa Le Boiteux, Anne Fogli, Mélanie Müller-Barthélémy, Catherine Vaurs‐Barrière, Emmanuel Chautard, Bruno Pereira, J. Biau, Jean‐Louis Kémény, Toufic Khalil, Lucie Karayan, Pierre Verrelle, Philippe Arnaúd
The paper investigates the role of DNA methylation and H3K27me3 in transcriptional alterations in glioma, finding that H3K27me3 defects are more prevalent than DNA methylation defects in gene deregulation.
bioRxiv · Feb 1, 2019Molecular Biology