Elisa Le Boiteux

This study uses multimodal mass spectrometry to accurately map co-occurring histone modifications on intact proteins, enabling residue-level assignment of modifications and positional isomers.

This paper introduces Arg-C Zero, a high-fidelity protease with near-zero missed cleavages, demonstrating its utility in proteomics, especially for analyzing post-translational modifications.

The paper investigates the role of DNA methylation and H3K27me3 in transcriptional alterations in glioma, finding that H3K27me3 defects are more prevalent than DNA methylation defects in gene deregulation.