Philippe Arnaúd

The elongation of Mest transcript into MestXL sustains, but does not initiate, the maternal allele bias of its convergent gene Copg2 during neurogenesis

The paper investigates the regulation of maternal allele bias in Copg2 during neurogenesis, showing it involves a two-step mechanism beyond MestXL-mediated interference.

Genomic imprinting of the metabolic regulator gene Klf14 is regulated by a paternal sub-TAD anchored at Mest and a shared enhancer in mice.

This paper identifies a paternal sub-TAD and shared enhancer that regulate Klf14 genomic imprinting in mice, revealing a mechanism involving Mest and allele-specific CTCF binding.

The RNA and protein landscapes of mouse brain organoids

This study characterizes the RNA and protein landscapes of mouse brain organoids, showing they closely resemble neonatal mouse brains and express synaptic proteins after three weeks of development.

Biallelic non-productive enhancer-promoter interaction precedes imprinted expression of Kcnk9 during mouse neural commitment

The paper investigates allele-specific enhancer-promoter interactions in an imprinted domain during mouse neural commitment, finding that biallelic interactions occur but only maternal ones are productive.

Most of transcriptional alterations in glioma result from DNA-methylation independent mechanisms

The paper investigates the role of DNA methylation and H3K27me3 in transcriptional alterations in glioma, finding that H3K27me3 defects are more prevalent than DNA methylation defects in gene deregulation.