SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses
Hsin-Ping Chiu, Yao Yu Yeo, Tsoi Ying Lai, Chuan-Tien Hung, Shreyas Kowdle, Griffin D. Haas, Sizun Jiang, Weina Sun, Benhur Lee
This study shows SARS-CoV-2 Nsp15 inhibits cGAS-STING-mediated antiviral responses by reducing cGAS and STING expression, thereby enhancing viral replication.
Journal of General Virology · Mar 25, 2026Peer-reviewedMicrobiology