Weina Sun

Optimizing an avian influenza vaccine using a novel Bacterial Enzymatic Combinatorial Chemistry (BECC) TLR4 adjuvant

This study evaluates a novel TLR4 adjuvant, BECC470s, in enhancing rHA vaccination against H5N1 influenza in mice, showing improved antibody responses but limited cross-neutralizing activity.

SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses

This study shows SARS-CoV-2 Nsp15 inhibits cGAS-STING-mediated antiviral responses by reducing cGAS and STING expression, thereby enhancing viral replication.

PUM2 binds SARS-CoV-2 RNA and PUM1 mildly reduces viral RNA levels, but neither protein affects progeny virus production

Enhancing protective efficacy and immunogenicity of hemagglutinin-based influenza vaccine utilizing adjuvants developed by BECC

This study evaluates BECC adjuvants' ability to enhance HA-based influenza vaccine efficacy in mice, showing improved immune responses and viral clearance.

Addressing SARS-CoV-2 Evolution: Neutralization of Emerging Variants of Concern by the AVX/COVID-12 'Patria' Vaccine Based on HexaPro-S Ancestral Wuhan Spike or Its Updated BA.2.75.2 Version

This study evaluates two SARS-CoV-2 vaccines, AVX/COVID-12 (V-Wu) and V-BA, showing V-BA provides better protection against Omicron subvariants while V-Wu offers broader coverage against multiple variants.

Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination

This study identifies non-neutralizing antibodies from vaccinated individuals that protect against SARS-CoV-2 in animal models, highlighting their role through Fc-mediated effector functions and conserved epitope binding.

Newcastle Disease Virus Vector-Based SARS-CoV-2 Vaccine Candidate AVX/COVID-12 Activates T Cells and Is Recognized by Antibodies from COVID-19 Patients and Vaccinated

This paper evaluates the AVX/COVID-12 vaccine's ability to activate T cells and bind antibodies from vaccinated individuals and SARS-CoV-2-infected patients.