Shreyas Kowdle

SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses

This study shows SARS-CoV-2 Nsp15 inhibits cGAS-STING-mediated antiviral responses by reducing cGAS and STING expression, thereby enhancing viral replication.

A temperature-sensitive and interferon-silent Sendai virus vector for CRISPR-Cas9 delivery and gene editing in primary human cells

This paper develops a temperature-sensitive and interferon-silent Sendai virus vector for CRISPR-Cas9 delivery, achieving high gene editing efficiency in human cells without triggering immune responses.

Tetracistronic Minigenomes Elucidate a Functional Promoter for Ghana Virus and Unveils Cedar Virus Replicase Promiscuity for all Henipaviruses

This paper develops tetracistronic minigenomes for henipaviruses to model their life cycle outside high biocontainment, revealing Cedar virus replicase promiscuity and functional GhV replicase with antiviral efficacy.

Paramyxovirus matrix proteins modulate host cell translation via exon-junction complex interactions in the cytoplasm

This study identifies how paramyxovirus matrix proteins inhibit host cell translation by interacting with the exon-junction complex, enhancing viral replication.

De novo antibody discovery in human blood from full-length single B cell transcriptomics and matching haplotyped-resolved germline assemblies

This study uses single-cell transcriptomics and germline haplotype assembly to discover antibodies from human blood post-MMR vaccination, showing neutralization of measles virus.

Structure guided mutagenesis of Henipavirus Receptor Binding Proteins reveals molecular determinants of receptor usage and antibody binding epitopes