Hsin-Ping Chiu

SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses

This study shows SARS-CoV-2 Nsp15 inhibits cGAS-STING-mediated antiviral responses by reducing cGAS and STING expression, thereby enhancing viral replication.

Paramyxovirus matrix proteins modulate host cell translation via exon-junction complex interactions in the cytoplasm

This study identifies how paramyxovirus matrix proteins inhibit host cell translation by interacting with the exon-junction complex, enhancing viral replication.

SARS-CoV-2 proteases cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species and the search for reservoir hosts.

This study identifies SARS-CoV-2 proteases NSP3 and NSP5 cleaving IRF3, NLRP12, and TAB1, which modulate inflammatory pathways, and explores implications for disease across species and potential reservoir hosts.