Loss of NKX2-1 predisposes thyroid to neoplasm development through regulation of oxidative stress
Yo-Taro Shirai, Jerrold Michael Ward, Yoshinori Takizawa, Huaitian Liu, Masaaki Miyakoshi, Manabu Iwadate, Tsubasa Murata, Suguru Hayase, Shigetoshi Yokoyama, Shogo Ehata, Shioko Kimura
The paper shows that loss of NKX2-1 increases thyroid cancer risk by promoting oxidative stress through ROS production and DNA damage in mice exposed to radiation and iodine deficiency.
bioRxiv · Aug 27, 2026 · PreprintCancer Biology