Shioko Kimura

The paper shows that loss of NKX2-1 increases thyroid cancer risk by promoting oxidative stress through ROS production and DNA damage in mice exposed to radiation and iodine deficiency.

The paper shows NKX2-1 uses differential chromatin binding to resolve opposing cell fates in mouse lung progenitors, with YAP/TAZ loss altering its binding sites and leading to transcriptional changes.