A PI(3,5)P2/ESCRT-III axis terminates STING signalling by facilitating TSG101-mediated lysosomal microautophagy
Tsumugi Shoji, Ayumi Shinojima, Satoshi Kusumi, Daisuke Koga, Kojiro Mukai, Jun Nakayama, Shigeki Higashiyama, Yoshihiko Kuchitsu, Tomohiko Taguchi
This study identifies the PI(3,5)P2/ESCRT-III axis as essential for STING degradation via lysosomal microautophagy, preventing sustained type I interferon responses.
bioRxiv · May 26, 2024 · PreprintCell Biology