Tuan Danh Anh Luu

This paper develops a high-quality, scalable workflow for whole-cell single-cell RNA sequencing of adult cardiomyocytes and non-myocytes using in-cell ligation and split-pool barcoding, improving data quality and throughput.

This study shows that loss of CTCF in mouse cardiomyocytes disrupts gene neighbourhoods, leading to ectopic enhancer-promoter interactions and heart failure.