Stefan Mueller

Mitochondrial turnover at central GABAergic synapses governs vulnerability to epileptic seizures

This study shows that mitochondrial turnover at GABAergic synapses affects seizure vulnerability, with gene therapy reversing the effects.

High throughput single-cell RNA sequencing of intact adult cardiomyocytes and non-myocytes using a split-pool approach

This paper develops a high-quality, scalable workflow for whole-cell single-cell RNA sequencing of adult cardiomyocytes and non-myocytes using in-cell ligation and split-pool barcoding, improving data quality and throughput.

System-Wide Proteomic Remodeling in Spinal Muscular Atrophy Reveals Tissue-Specific Responses and Partial Rescue by SMN Restoration

This study uses proteomics to show that SMN deficiency causes tissue-specific proteome changes in SMA, with partial rescue by SMN restoration but incomplete recovery of metabolic pathways.

SMN deficiency disrupts hepatic mitochondrial iron homeostasis and NRF2-dependent redox control in spinal muscular atrophy

This study identifies mitochondrial-iron-redox dysregulation in SMA liver, showing early ferroptotic vulnerability and persistent heme pathway activation despite SMN restoration.

Harmine Selectively Drives Human Beta Cell Differentiation and Function Via Protein Kinase A Pathways

This paper shows harmine, a DYRK1A inhibitor, selectively promotes human beta cell differentiation and function via PKA activation, distinct from other DYRK1A inhibitors.