Human Peripheral Nerve-on-a-Chip on a Multiwell Microelectrode Array as a Scalable Preclinical Neurotoxicity Assay
Corey M. Rountree, Tyler Rodriguez, Ethan Byrne, Eva Schmidt, Erin Schwarzbach, Sabrina Dillon, Ally McCrimmon, Megan Terral, Monica R. Metea, Michael John Moore, J. Lowry Curley
This paper introduces a 3D peripheral nerve-on-a-chip model to predict neurotoxicity, showing it captures dose- and time-dependent nerve damage similar to human clinical exposures.
bioRxiv · Jun 9, 2025 · PreprintPharmacology & Toxicology