J. Lowry Curley

Long-Term Potentiation and Closed-Loop Learning in Paired Brain Organoids for CNS Drug Discovery

This study demonstrates LTP and closed-loop learning in paired brain organoids, showing BDNF's role in enhancing plasticity and linking game performance to cognitive function for CNS drug discovery.

Human Peripheral Nerve-on-a-Chip on a Multiwell Microelectrode Array as a Scalable Preclinical Neurotoxicity Assay

This paper introduces a 3D peripheral nerve-on-a-chip model to predict neurotoxicity, showing it captures dose- and time-dependent nerve damage similar to human clinical exposures.