Corey M. Rountree

The paper uses human CNS-3D organoids to predict clinical seizure liability based on calcium network activity, achieving high sensitivity and specificity.

This study demonstrates LTP and closed-loop learning in paired brain organoids, showing BDNF's role in enhancing plasticity and linking game performance to cognitive function for CNS drug discovery.

This paper introduces a 3D peripheral nerve-on-a-chip model to predict neurotoxicity, showing it captures dose- and time-dependent nerve damage similar to human clinical exposures.