Chitin oligomers induce atypical NLRP3 inflammasome activation and innate immune training
Timmy Richardo, Margareta J. Hellmann, Tzu-Hsuan Chang, Jumana Kushkush, Xiao Liu, Bruno Maria Moerschbacher, Alexander N.R. Weber
This study shows that chitin oligomers of specific lengths activate the NLRP3 inflammasome and induce innate immune training through phagocytosis and methyl transferase activity.
bioRxiv · Jun 22, 2026 · PreprintImmunology