Cancer BiologybioRxivPreprint
Spatial Biology and Organoid Technologies Reveal a Potential Therapy-Resistant Cancer Stem Cell Population in Pancreatic Ductal Adenocarcinoma
Pritha Adhikary, Jayati L. Chakrabarti, Saptarshi Mallick…·Yana L. Zavros
The paper uses spatial imaging and organoid models to identify therapy-resistant CD44v9+ cancer stem cells in PDAC and show that cabozantinib may enhance immunotherapy by altering the tumor microenvironment.