Author

Saptarshi Mallick

University of ArizonaORCID 0000-0002-0797-8154Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:imaging· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Jayati L. ChakrabartiiD· 2 shared Abigail G. Branch· 1 shared Alexander Borowiec· 1 shared Curtis A. ThorneiD· 1 shared Elliott B. BurdetteiD· 1 shared Eugene DouglassiD· 1 shared Frédéric HollandeiD· 1 shared Gregory Lawrence BeattyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCell Biology

Jayati L. ChakrabartiORCID

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2 papers

Recent·Most cited

Preservation of Human Colonic Stem Cells Requires an ERK Dynamics Checkpoint Mediated by AKT

Lauren Riede, Alexander Borowiec, Saptarshi Mallick, Sohini Mallick, Jayati L. Chakrabarti, Curtis A. Thorne, Kelvin W. Pond

The paper shows that human colonic stem cells use an AKT-dependent ERK dynamics checkpoint to maintain tissue homeostasis by suppressing differentiation-inducing ERK pulses.

bioRxiv · Apr 11, 2026 · PreprintCell Biology

Spatial Biology and Organoid Technologies Reveal a Potential Therapy-Resistant Cancer Stem Cell Population in Pancreatic Ductal Adenocarcinoma

Pritha Adhikary, Jayati L. Chakrabarti, Saptarshi Mallick, Xi Sun, Ugonna Ezuma-Igwe, Abigail G. Branch, Jiang Wang, Nicolas Braissand, Megan P. Corbett, Sangmin Kim, Rohan Kanakamedala, Willian C. Bastian, Eugene Douglass, Meenu Priya Resmi, Payton D. Stevens, , Yana L. Zavros

The paper uses spatial imaging and organoid models to identify therapy-resistant CD44v9+ cancer stem cells in PDAC and show that cabozantinib may enhance immunotherapy by altering the tumor microenvironment.

bioRxiv · May 22, 2025 · PreprintCancer Biology