Frédéric Hollande

This study uses genetic barcoding to analyze clonal composition in solid and liquid biopsies of breast cancer models, revealing differences in clonal diversity and DNA shedding patterns.

The paper uses spatial imaging and organoid models to identify therapy-resistant CD44v9+ cancer stem cells in PDAC and show that cabozantinib may enhance immunotherapy by altering the tumor microenvironment.

This study identifies the netrin-1/UNC5B/TFF3 axis as a regulator of colorectal cancer stem cell self-renewal and shows that targeting it with NP137 enhances chemotherapy efficacy in preclinical models.