Maturation of Hippocampus-Medial Prefrontal Cortex Projections Defines a Pathway-Specific Sensitive Period for Cognitive Flexibility
Arely Cruz-Sanchez, Kathleen E. LaDouceur, Anusha Abdusalom, Helen Chasiotis, Radu Gugustea, Mehreen Inayat, Unza Mumtaz, Maryam Hasantash, Christoph Anacker, Maithé Arruda-Carvalho
This study examines the development of hippocampus-mPFC projections in mice, finding that juvenile inhibition of specific pathways affects adult cognitive flexibility in a sex- and pathway-specific manner.
Cell Reports · Jan 1, 2026Peer-reviewedNeuroscience