NeuroscienceJCI InsightPeer-reviewed
Inhibition of the angiotensin-converting enzyme N-terminal catalytic domain prevents endogenous opioid degradation in brain tissue
Filip Hanak, Jessica L. Swanson, Krzysztof Felczak…·Patrick E. Rothwell
This study identifies the N-terminal catalytic domain of ACE as the primary site for endogenous opioid peptide degradation in brain tissue and shows that inhibiting this domain reduces opioid degradation.
1 citation