Author

B. P. Riesenberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cancer Biology· 1

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Research Focus:cancer & tumor microenvironment· 4 Approach:experimental assay· 4 Organism:human· 4 Organism:mouse· 4 Approach:statistical model· 4 Assay:metabolomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

J. E. Thaxton· 5 shared E. G. Hunt· 3 shared K. E. Hurst· 3 shared P. Gao· 3 shared A. M. Andrews· 2 shared A. S. Kennedy· 2 shared E. J. Gandy· 2 shared J. J. Milner· 2 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersImmunology

J. E. Thaxton

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Author profile →

5 papers

Recent·Most cited

Tirzepatide restricts obesity-related tumor growth by reversing metabolic dysregulation and rescuing CD8+ T cell function

E. M. Glenny, M. F. Coleman, G. T. Clutton, B. P. Riesenberg, A. N. Ho, T. L. McFarlane, V. A. Kiesel, A. L. Kucinskas, E. G. Bailey, K. E. Sanchez, J. Zeng, Y. Wang, H. M. Malian, C. E. Gates, F. Chen, , S. D. Hursting

This study shows tirzepatide reduces obesity-related tumor growth by improving metabolism and restoring CD8+ T cell function without directly targeting cancer cells.

bioRxiv · Jan 20, 2024 · PreprintCancer Biology

Acetyl-CoA Carboxylase Obstructs CD8+ T-Cell Lipid Utilization and Energy Synthesis in the Tumor Microenvironment

E. G. Hunt, K. E. Hurst, B. P. Riesenberg, A. S. Kennedy, E. J. Gandy, A. M. Andrews, E. D. Wallace, P. Gao, M. Coleman, J. E. Thaxton

This study shows that acetyl-CoA carboxylase (ACC) activity in T cells within the tumor microenvironment inhibits lipid utilization and energy synthesis, and its restriction enhances T cell survival and antitumor function.

bioRxiv · Nov 16, 2023 · PreprintImmunology

Adaptive IRE1 Signaling Elicits T Cell Metabolic Remodeling and Tumor Control

B. P. Riesenberg, E. J. Gandy, A. S. Kennedy, E. G. Hunt, K. E. Hurst, E. L. Sedlacek, P. Gao, M. J. Emanuele, J. Modliszewski, J. M. Green, J. J. Milner, L. Wiseman, J. E. Thaxton

This study shows that enhancing the adaptive IRE1 UPR pathway in T cells improves tumor control by reducing mitochondrial toxicity and chronic ER stress.

bioRxiv · Nov 16, 2023 · PreprintImmunology

Atlas-Guided Discovery of Transcription Factors for T Cell Programming

H. K. Chung, C. Liu, A. Battu, A. N. Jambor, B. M. Pratt, F. Xie, B. P. Riesenberg, E. Casillas, M. Sun, E. Landoni, Y. Li, Q. Ye, D. Joo, J. Green, Z. Syed, , S. M. Kaech

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

bioRxiv · Jan 3, 2023Immunology

Stress-Mediated Attenuation of Translation Undermines T Cell Tumor Control

B. P. Riesenberg, E. G. Hunt, M. D. Tennant, K. E. Hurst, A. M. Andrews, L. R. Leddy, D. M. Neskey, E. G. Hill, G. O. R. Rivera, C. M. Paulos, P. Gao, J. E. Thaxton

This study shows that solid tumor microenvironment stress reduces T cell protein translation via the UPR and p-eIF2, and that proteasome stimulation can reverse this effect to enhance antitumor immunity.

bioRxiv · Jan 31, 2022 · PreprintImmunology