Author

V. B. P. Leite

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6

Signature Assays, Organisms & Methods

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Approach:statistical model· 6 Approach:deep learning· 4 Research Focus:protein folding & dynamics· 4 Assay:protein structure· 3 Research Focus:benchmarking· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. B. Oliveira Junior· 3 shared J. N. Onuchic· 3 shared R. G. Viegas· 3 shared I. B. S. Martins· 2 shared M. N. Sanches· 2 shared A. Sahoo· 1 shared E. Dodero-Rojas· 1 shared F. V. Paulovich· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiophysics

A. B. Oliveira Junior

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6 papers

Recent·Most cited

Understanding the Energy Landscape of Intrinsically Disordered Protein Ensembles

R. G. Viegas, I. B. S. Martins, V. B. P. LEITE

This study uses ELViM to analyze IDP ensembles from PED, validating their sampling and identifying prevalent conformations and differences across conditions.

Journal of Chemical Information and Modeling · May 7, 2024Peer-reviewedBiophysics

ELViM: Understanding Molecular Energy Landscape

R. G. Viegas, I. B. S. Martins, M. N. Sanches, A. B. Oliveira Junior, J. B. de Camargo, F. V. Paulovich, V. B. P. Leite

ELViM is a multidimensional reduction technique for analyzing MD simulation data, demonstrating its ability to visualize complex biomolecular conformational landscapes.

bioRxiv · Jan 4, 2024Biophysics

Molecular dynamics simulations illuminate the role of sequence context in the ELF3-PrD-based temperature sensing mechanism in plants

R. J. Lindsay, A. Sahoo, R. G. Viegas, V. B. P. Leite, P. A. Wigge, S. M. Hanson

The paper uses molecular dynamics simulations to show how sequence context and polyQ tract length affect temperature-dependent condensate formation in ELF3-PrD, influencing plant growth responses.

bioRxiv · Mar 15, 2023 · PreprintBiophysics

Examining the Ensembles of Amyloid-β Monomer Variants and their Propensities to Form Fibers Using an Energy Landscape Visualization Method

M. N. Sanches, K. Knapp, A. B. Oliveira Junior, P. G. Wolynes, J. N. Onuchic, V. B. P. LEITE

This study uses ELViM to analyze Aβ40 and Aβ42 monomers and their mutations, showing how ELViM distinguishes fiber-forming from non-fiber-forming variants.

bioRxiv · Oct 28, 2021Biophysics

Exploring Energy Landscapes of Intrinsically Disordered Proteins: Insights into Functional Mechanisms

A. B. Oliveira Junior, X. Lin, P. Kulkarni, J. N. Onuchic, S. Roy, V. B. P. Leite

This paper introduces ELViM, a reaction coordinate-free method to analyze energy landscapes of IDPs, revealing conformational differences between phosphoforms of PAGE4.

bioRxiv · Jan 28, 2021Biophysics

Modeling Mayaro and Chikungunya Control Strategies in Rio de Janeiro Outbreaks

E. Dodero-Rojas, L. G. Ferreira, V. B. P. Leite, J. N. Onuchic, V. d. G. Contessoto

The paper analyzes Chikungunya outbreaks in Rio de Janeiro using a compartmental model to estimate the basic reproduction number and simulate public intervention scenarios for Mayaro virus.

bioRxiv · Sep 11, 2019Biophysics