P. Kulkarni

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4

This study identifies PPTC7 as a cofactor for SCFFBXL4-mediated degradation of BNIP3 and NIX, suppressing mitophagy and revealing a feedback mechanism to regulate mitochondrial homeostasis.

N-linked glycosylation of the M-protein variable region: Glycoproteogenomics reveals a new layer of personalized complexity in multiple myeloma.

This study introduces a glycoproteogenomics method to analyze N-glycosylation of M-protein variable regions in multiple myeloma, revealing increased glycan complexity in patient samples compared to healthy controls.

FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors

This study identifies FBXL4 as a suppressor of basal mitophagy by ubiquitylating and degrading NIX and BNIP3, and shows pathogenic variants disrupt this function leading to mtDNA depletion syndrome.

Exploring the interspecific interactions and the metabolome of the soil isolate Hylemonella gracilis

This study isolates and characterizes small soil bacteria, showing they can interact with other soil bacteria to alter gene expression and metabolism, suggesting they contribute to soil microbial symbiosis.

Exploring Energy Landscapes of Intrinsically Disordered Proteins: Insights into Functional Mechanisms

This paper introduces ELViM, a reaction coordinate-free method to analyze energy landscapes of IDPs, revealing conformational differences between phosphoforms of PAGE4.

The Ephrin receptor A2 and Roundabout Guidance Receptor 1 heterodimer: A potential theranostic for squamous cell carcinomas

The paper shows that the EPHA2-ROBO1 heterodimer reduces growth of lung and head and neck squamous cell carcinomas and suggests SLIT2 and Ensartinib as potential therapies.

Suppressing chemoresistance in lung cancer via dynamic phenotypic switching and intermittent therapy

This study shows that intermittent chemotherapy can suppress chemoresistance in lung cancer by preventing the emergence of tolerant cells through dynamic phenotypic switching.

A Non-genetic Mechanism for Chemoresistance in Lung Cancer: The Role of Integrin β4/Paxillin Axis

This study identifies a non-genetic mechanism for cisplatin resistance in lung adenocarcinoma involving the integrin β4/paxillin axis and its regulation of USP1 and VDAC1.

Phenotypic Switching of Naïve T cells to Immune-suppressive Treg-like Cells by Mutant KRAS

The paper shows mutant KRAS induces T cells to become immune-suppressive Treg-like cells through exosomes, sera, or direct transfection, with single-cell sequencing identifying the interferon pathway as the mechanism.

Cancer/Testis Antigens Differentially Expressed in Prostate Cancer: Potential New Biomarkers and Targets for Immunotherapies

This study identifies a panel of cancer/testis antigens differentially expressed in metastatic prostate cancer, showing potential as biomarkers for diagnosis and immunotherapy targets.

Phylogenetic and Spatial Distribution of Evolutionary Isolation and Threat in Turtles and Crocodilians (Non-Avian Archosauromorphs)

The paper assesses threat status and evolutionary distinctiveness of turtles and crocodilians using phylogenetic analysis and machine learning, finding extinction risk increases with evolutionary distinctiveness and geographic factors.

LAESI mass spectrometry imaging as a tool to differentiate the root metabolome of native and range-expanding plant species

This study uses LAESI-MSI to compare root metabolomes of native and range-expanding plant species, finding distinct metabolic fingerprints suggesting greater diversity in range-expanding species.

PAGE4 and Conformational Switching: Insights from Molecular Dynamics Simulations and Implications for Prostate Cancer

This study uses molecular dynamics simulations to investigate how phosphorylation of PAGE4 affects its structure and interactions with AP-1 and AR, revealing conformational switching linked to prostate cancer progression.