Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin
V. Byles, Y. Cormerais, K. Kalafut, V. Barrera, J. E. Hughes Hallett, S. Ho Sui, J. M. Asara, C. M. Adams, G. Hoxhaj, I. Ben-Sahra, B. D. Manning
This study shows that mTORC1 activates ATF4 in the liver to regulate amino acid metabolism during feeding and insulin signaling.
bioRxiv · May 2, 2021Cell Biology