Author

C. M. Adams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:metabolism & bioenergetics· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2

Frequent Co-Authors

A. Marti· 2 shared E. D. Abel· 2 shared E. T. Weatherford· 2 shared L. M. G. Pena· 2 shared M. J. Potthoff· 2 shared R. O. Pereira· 2 shared S. H. Bjorkman· 2 shared A. C. Olvera· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersPhysiology

A. Marti

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

ATF4 Expression in Thermogenic Adipocytes is Required for Cold-Induced Thermogenesis in Mice via FGF21-Independent Mechanisms

S. H. Bjorkman, A. Marti, J. Jena, L. M. G. Pena, E. T. Weatherford, K. Kato, J. Koneru, J. H. Chen, A. Sood, M. J. Potthoff, C. M. Adams, E. D. Abel, R. O. Pereira

This study shows ATF4 is essential for cold-induced thermogenesis in mice through amino acid metabolism, independent of FGF21, while FGF21 is not required for thermoregulation.

bioRxiv · Mar 9, 2023Physiology

Biphasic response of CD8 T cell to asparagine restriction maximizes its metabolic fitness and antitumoral functionality

J. R. Gnanaprakasam, L. Liu, X. Chen, S. Kang, T. Wang, T. A. Cassel, C. M. Adams, R. M. Higashi, D. A. Scott, G. Xin, J. Yang, A. N. Lane, T. W. Fan, J. Zhang, R. Wang

This study shows that asparagine restriction induces a biphasic response in CD8 T cells, enhancing their metabolic fitness and antitumoral function through ATF4/NRF2-dependent mechanisms.

bioRxiv · Jul 18, 2022 · PreprintImmunology

Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin

V. Byles, Y. Cormerais, K. Kalafut, V. Barrera, J. E. Hughes Hallett, S. Ho Sui, J. M. Asara, C. M. Adams, G. Hoxhaj, I. Ben-Sahra, B. D. Manning

This study shows that mTORC1 activates ATF4 in the liver to regulate amino acid metabolism during feeding and insulin signaling.

bioRxiv · May 2, 2021Cell Biology

OPA1 Deletion in Brown Adipose Tissue Improves Thermoregulation and Systemic Metabolism via FGF21

R. O. Pereira, A. Marti, A. C. Olvera, S. M. Tadinada, S. H. Bjorkman, E. T. Weatherford, M. Westphal, P. H. Patel, A. K. Kirby, R. Hewezi, W. Bui Tran, L. M. G. Pena, R. A. Souvenir, M. Mital, C. M. Adams, , E. D. Abel

This study shows that deleting OPA1 in brown adipose tissue enhances thermoregulation and metabolism through the ATF4-FGF21 pathway, independent of thermogenesis.

bioRxiv · Jan 4, 2021Physiology

MYC regulates ribosome biogenesis and mitochondrial gene expression programs through interaction with Host Cell Factor-1

T. M. Popay, J. Wang, C. M. Adams, S. G. Codreanu, S. D. Sherrod, J. A. McLean, L. R. Thomas, S. L. Lorey, Y. J. Machida, A. M. Weissmiller, C. M. Eischen, Q. Liu, W. Tansey

This study identifies HCF-1 as a critical co-factor for MYC in driving mitochondrial and ribosome biogenesis gene expression, and shows its impact on cell growth and tumor progression.

bioRxiv · Jun 22, 2020Cancer Biology