I. Ben-Sahra

Exploiting De Novo Serine Synthesis as a Metabolic Vulnerability to Overcome Sunitinib Resistance in Advanced Renal Cell Carcinoma

This study identifies serine synthesis as a metabolic vulnerability in sunitinib-resistant renal cell carcinoma, showing that inhibiting key enzymes enhances drug sensitivity.

HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma

This study shows that Group 3 medulloblastoma cells rely on HIF-2 instead of HIF-1 for hypoxia adaptation, and inhibiting HIF-2 with metformin kills these cells more effectively than non-Group 3 cells.

ASCT2 is the primary serine transporter in cancer cells

This study identifies ASCT2 as the primary serine transporter in cancer cells and shows its role in purine biosynthesis and therapeutic targeting.

Mechano-dependent sorbitol accumulation supports biomolecular condensate

The paper shows matrix stiffening promotes biomolecular condensation via sorbitol, a mechanosensitive metabolite, and demonstrates this in breast cancer.

Ribonucleotide Reductase Regulatory Subunit M2 as a Driver of Glioblastoma TMZ-Resistance through Modulation of dNTP Production

This study identifies RRM2 as a driver of TMZ resistance in GBM by modulating dNTP production, showing RRM2 inhibition enhances TMZ efficacy in vivo.

The hexokinase ''HKDC1'' interaction with the mitochondria is essential for hepatocellular carcinoma progression

This study shows that HKDC1's interaction with mitochondria is critical for HCC progression by altering metabolism and causing mitochondrial dysfunction.

Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin

This study shows that mTORC1 activates ATF4 in the liver to regulate amino acid metabolism during feeding and insulin signaling.

Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ macrophages

This study identifies CD38+ macrophages as a driver of NAD decline during aging through inflammation linked to cellular senescence in metabolic tissues.