Author

B. D. Manning

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:metabolism & bioenergetics· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. M. Asara· 3 shared A. J. Valvezan· 2 shared M. E. Torrence· 2 shared A. M. Hosios· 1 shared A. Valvezan· 1 shared B. E. Housden· 1 shared C. Kelley· 1 shared C. M. Adams· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCell Biology

J. M. Asara

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Author profile →

4 papers

Recent·Most cited

Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin

V. Byles, Y. Cormerais, K. Kalafut, V. Barrera, J. E. Hughes Hallett, S. Ho Sui, J. M. Asara, C. M. Adams, G. Hoxhaj, I. Ben-Sahra, B. D. Manning

This study shows that mTORC1 activates ATF4 in the liver to regulate amino acid metabolism during feeding and insulin signaling.

bioRxiv · May 2, 2021Cell Biology

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

M. E. Torrence, M. R. MacArthur, A. M. Hosios, A. Valvezan, J. M. Asara, J. R. Mitchell, B. D. Manning

This study shows that mTORC1 activates ATF4 to promote protein and glutathione synthesis, distinct from ISR-mediated ATF4 activation.

bioRxiv · Oct 3, 2020Cell Biology

IMPDH inhibitors for anti-tumor therapy in tuberous sclerosis complex

A. J. Valvezan, S. K. Miller, M. C. McNamara, M. E. Torrence, J. M. Asara, E. P. Henske, B. D. Manning

This paper evaluates IMPDH inhibitors for anti-tumor therapy in TSC, finding mizoribine more effective than mycophenolic acid in targeting mTORC1-driven tumors.

bioRxiv · Nov 11, 2019Cancer Biology

Variable dose analysis: A novel RNAi-based method for detection of synthetic lethal interactions

B. E. Housden, Z. Li, C. Kelley, Y. Wang, Y. Hu, A. J. Valvezan, B. D. Manning, N. Perrimon

This paper introduces a novel RNAi-based method called variable dose analysis (VDA) to detect synthetic lethal interactions, identifying four FDA-approved drugs for TSC-related tumors.

bioRxiv · Aug 16, 2017Cancer Biology