Homeostatic responses to hypoxia by the carotid body and adrenal medulla are based on mutual antagonism between HIF-1α and HIF-2α
G. Yuan, Y.-J. Peng, V. D. Reddy, V. Makarenko, J. Nanduri, S. A. Khan, J. A. Garcia, G. K. Kumar, G. L. Semenza, N. R. Prabhakar
This study shows that HIF-1α and HIF-2α antagonism in the carotid body and adrenal medulla regulates redox balance and hypoxia responses, maintaining blood pressure and respiration.
bioRxiv · Jul 11, 2022 · PreprintPhysiology