S. A. Khan

Cellular stemness identifies high-risk ductal carcinoma in situ and offers a therapeutic interception opportunity

This study identifies stemness features in luminal hormone-responsive cells within DCIS that correlate with invasive progression and shows that targeting FOXA1 reduces tumor growth.

Metabolic shift to serine pathway induced by lipids confers oncogenic properties in non-transformed breast cells

The paper shows that lipid metabolism, specifically through OA, shifts metabolic pathways in breast cells, increasing SAM and 2-HG, which contribute to oncogenic properties and epigenetic changes.

Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancer

This study investigates how nutrient supply affects ASNS and GPER1 expression in KRAS mutant and wild-type colorectal cancer cells and their association with patient survival.

A comparative study of low-pH tolerance and chitinase activity between toxigenic and non-toxigenic strains of Vibrio cholerae

This study compares low-pH tolerance and chitinase activity between toxigenic and non-toxigenic Vibrio cholerae strains, finding that the non-toxigenic strain exhibits greater growth and chitinase activity under acidic conditions.

Indigenous Reduction of Multi-drug Resistant Bacterial Pathogens in a Natural Uncontrolled Fermented Milk Ecosystem

This study assesses the microbiological safety and antibiotic resistance of raw milk and dahi, finding reduced pathogen prevalence and inhibitory effects in dahi due to fermentation.

Homeostatic responses to hypoxia by the carotid body and adrenal medulla are based on mutual antagonism between HIF-1α and HIF-2α

This study shows that HIF-1α and HIF-2α antagonism in the carotid body and adrenal medulla regulates redox balance and hypoxia responses, maintaining blood pressure and respiration.

A recombinant selective drug-resistant M. bovis BCG enhances the bactericidal activity of a second-line tuberculosis regimen

This study develops a drug-resistant recombinant BCG vaccine that enhances second-line TB treatment efficacy in a murine model of drug-resistant tuberculosis.

Molecular pathway analysis indicates a distinct metabolic and immune phenotype in women with right-sided colon cancer

This study identifies a distinct metabolic and immune phenotype in women with right-sided colon cancer through gene expression analysis of public datasets.

Animal model and therapeutic prospects for left ventricular hypertrophy and associated renal complication

This study investigates the effects of hydrogen sulphide (H2S) and nitric oxide (NO) treatments on gene expression and physiological indices in a rat model of left ventricular hypertrophy (LVH) and associated renal complications, showing therapeutic potential of combined H2S+NO treatment.

Deep learning for cancer type classification

This study introduces DeepCues, a deep learning model that improves cancer type classification using DNA sequencing data, achieving 77.6% accuracy on TCGA data and showing significant improvement over conventional methods.