G. Yuan

Trojan horse virus delivering CRISPR-AsCas12f1 controls plant bacterial wilt caused by Ralstonia solanacearum

This paper develops an engineered filamentous phage that delivers CRISPR-AsCas12f1 to target Ralstonia solanacearum's virulence gene hrpB, effectively controlling bacterial wilt in tobacco.

Rationale design of unrestricted pRN1 derivatives and their application in construction of a dual plasmid vector system for Saccharolobus islandicus

The paper designs mutated pRN1 plasmid backbones to evade CRISPR immunity in Saccharolobus islandicus, enabling stable plasmid vectors and a dual plasmid system for genetic studies.

Sustained store-operated calcium entry utilizing activated chromatin state leads to instability in iTregs

This study shows that sustained store-operated calcium entry (SOCE) and chromatin accessibility in iTregs lead to phenotypical instability, unlike tTregs.

Functional analysis of Salix purpurea genes support roles for ARR17 and GATA15 as master regulators of sex determination

This study functionally characterizes candidate sex determination genes in Salix purpurea using Arabidopsis, supporting ARR17 and GATA15 as master regulators and identifying downstream transcription factors.

Split selectable marker mediated gene stacking in plants

This paper introduces a split selectable marker system using inteins for Agrobacterium-mediated co-transformation in plants, enabling the simultaneous insertion of multiple genes into Arabidopsis and poplar.

Analysis of sex differential genes at whole genome level reveals their organ- and chromosome-dependent expressions, regulations, and interactions

The paper analyzes sex differential genes across seven tissues in BXD mouse strains, revealing organ- and chromosome-dependent expression patterns and functional roles.

The effector recognition by synthetic sensor NLR receptors requires the concerted action of multiple interfaces within and outside the integrated domain

This study shows that synthetic sensor NLR receptors require multiple interfaces within and outside their integrated domain to recognize noncorresponding effectors and activate resistance.

Homeostatic responses to hypoxia by the carotid body and adrenal medulla are based on mutual antagonism between HIF-1α and HIF-2α

This study shows that HIF-1α and HIF-2α antagonism in the carotid body and adrenal medulla regulates redox balance and hypoxia responses, maintaining blood pressure and respiration.

An intein-mediated split-nCas9 system for base editing in plants

This paper develops a split-nCas9 system using intein-mediated reassembly for efficient base editing in plants.

Plant-based biosensors for detecting CRISPR-mediated genome engineering

This study develops plant-based biosensors to detect CRISPR/Cas tools in real-time, demonstrating their effectiveness in detecting various CRISPR functions in multiple plant species.

Identification of biomarkers and pathways of mitochondria in sepsis patients

This study identifies mitochondrial biomarkers and pathways in sepsis using bioinformatics analysis of gene expression data from a public dataset.

Identification of biomarkers and candidate regulators for multiple myeloma under the knockout of AURKA

This study identifies biomarkers and candidate regulators in multiple myeloma under AURKA knockout using bioinformatics analysis of gene expression data.

Comparative secretome of Magnaporthe oryzae identified proteins involved in virulence and cell wall integrity

This study compares the secretome of Magnaporthe oryzae wild type and Δalg3 mutants, identifying 51 proteins requiring ALG3 for secretion and showing their roles in virulence and cell wall integrity.

Kaposi sarcoma-associated herpesvirus infection in HIV patients: potential role of HIV-associated extracellular vesicles

This study shows HIV-associated extracellular vesicles enhance KSHV infectivity in oral epithelial cells via TAR RNA and EGFR, suggesting EGFR inhibition as a potential therapeutic strategy.

The role of Cdx2 as a lineage specific transcriptional repressor for pluripotent network during trophectoderm and inner cell mass specification

This study identifies CDX2-regulated genes and regulatory elements in mouse embryos, revealing how CDX2 represses pluripotent genes during trophectoderm and inner cell mass specification.