Author

V. Faundez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1

Frequent Co-Authors

A. Gokhale· 2 shared B. R. Roberts· 2 shared C. Xu· 2 shared E. Werner· 2 shared N. T. Seyfried· 2 shared Z. Wen· 2 shared A. Barrientos· 1 shared A. Crocker· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCell Biology

A. Gokhale

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Author profile →

3 papers

Recent·Most cited

APOE Expression and Secretion are Modulated by Mitochondrial Dysfunction

M. E. Wynne, O. Ogunbona, A. R. Lane, A. Gokhale, S. A. Zlatic, C. Xu, Z. Wen, D. Duong, S. Rayaprolu, A. Ivanova, E. A. Ortlund, E. B. Dammer, N. T. Seyfried, B. R. Roberts, A. Crocker, , V. Faundez

This study shows mitochondrial dysfunction increases APOE expression and secretion in multiple cell types and models, linking mitochondrial health to Alzheimer's disease risk.

bioRxiv · May 11, 2022Cell Biology

The Mitochondrial RNA Granule Modulates Manganese-Dependent Cell Toxicity

E. Werner, A. Gokhale, M. Ackert, C. Xu, Z. Wen, A. M. Roberts, B. R. Roberts, A. R. Vrailas-Mortimer, A. J. Crocker, V. Faundez

This study identifies the mitochondrial RNA granule as a protective mechanism against manganese toxicity by showing its downregulation enhances cell survival.

bioRxiv · Jan 4, 2022Cell Biology

Mitochondrial energy dysfunction induces remodeling of the cardiac mitochondrial protein acylome

J. N. Peoples, N. Ghazal, D. M. Duong, K. R. Hardin, N. T. Seyfried, V. Faundez, J. Q. Kwong

This study shows that mitochondrial energy dysfunction in the heart causes acylome remodeling, including increased acetylation and malonylation of mitochondrial proteins, with functional consequences for IDH2 and SIRT5.

bioRxiv · Jan 31, 2021Cell Biology