APOE Expression and Secretion are Modulated by Mitochondrial Dysfunction
M. E. Wynne, O. Ogunbona, A. R. Lane, A. Gokhale, S. A. Zlatic, C. Xu, Z. Wen, D. Duong, S. Rayaprolu, A. Ivanova, E. A. Ortlund, E. B. Dammer, N. T. Seyfried, B. R. Roberts, A. Crocker, , V. Faundez
This study shows mitochondrial dysfunction increases APOE expression and secretion in multiple cell types and models, linking mitochondrial health to Alzheimer's disease risk.
bioRxiv · May 11, 2022Cell Biology