IF1 is a cold-regulated switch of ATP synthase to support thermogenesis in brown fat
H. S. Brunetta, A. S. Jung, F. B. Valdivieso-Rivera, S. C. C. Zani, V. Furino, A. Francisco, P. M. M. Moraes-Vieira, S. Keipert, M. Jastroch, L. O. Martinez, C. H. Sponton, R. F. Castilho, M. A. Mori, A. Bartelt
This paper identifies IF1 as a cold-regulated inhibitor of ATP synthase that facilitates reverse mode activity in brown fat to support thermogenesis.
bioRxiv · Jul 27, 2023 · PreprintCell Biology