Author

V. G. Giacobelli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

K. Hlouchova· 3 shared K. Fujishima· 2 shared L. Bednarova· 2 shared M. Makarov· 2 shared V. Tretyachenko· 2 shared A. Brezinova· 1 shared A. C. Sanchez Rocha· 1 shared A. K. Dunker· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersBiochemistry

K. Hlouchova

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3 papers

Recent·Most cited

The interplay between peptides and RNA is critical for protoribosome compartmentalization and stability

S. Codispoti, T. Yamaguchi, M. Makarov, V. G. Giacobelli, M. Masek, M. H. Kolar, A. C. Sanchez Rocha, K. Fujishima, G. Zanchetta, K. Hlouchova

This paper investigates the role of ribosomal peptides in protoribosome compartmentalization and stability, showing that RNA-protein interactions protect RNA from degradation and influence structural flexibility.

bioRxiv · Jan 29, 2024Biophysics

In vitro evolution reveals primordial RNA-protein interaction mediated by metal cations

V. G. Giacobelli, K. Fujishima, M. Lepsik, V. Tretyachenko, T. Kadava, L. Bednarova, P. Novak, K. Hlouchova

This study uses in vitro evolution to show that RNA-protein interactions in early life could be mediated by metal cations and acidic residues instead of aromatic/basic amino acids.

bioRxiv · Aug 1, 2021 · PreprintBiochemistry

Enzyme catalysis prior to aromatic residues: reverse engineering of a dephosphoCoA kinase

M. Makarov, J. Meng, V. Tretyachenko, P. Srb, A. Brezinova, V. G. Giacobelli, L. Bednarova, J. Vondrasek, A. K. Dunker, K. Hlouchova

This study shows that enzyme catalysis can occur without aromatic amino acids by testing variants of dephosphoCoA kinase with reduced amino acid alphabets.

bioRxiv · Nov 11, 2020Biochemistry