Author

L. Bednarova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:snRNA-seq· 1

Frequent Co-Authors

K. Hlouchova· 2 shared V. G. Giacobelli· 2 shared V. Tretyachenko· 2 shared A. Brezinova· 1 shared A. K. Dunker· 1 shared A. Skriba· 1 shared B. Benoni· 1 shared D. Stanek· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

K. Hlouchova

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Author profile →

3 papers

Recent·Most cited

HIV-1 infection reduces NAD capping of host cell snRNA and snoRNA

B. Benoni, J. F. Potuznik, A. Skriba, R. Benoni, J. Trylcova, M. Tulpa, K. Spustova, K. Grab, M.-B. Mititelu, J. Paces, J. Weber, D. Stanek, J. Kowalska, L. Bednarova, Z. Keckesova, , H. Cahova

This study shows HIV-1 infection reduces NAD capping of host snRNA and snoRNA, leading to increased HIV-1 infectivity by destabilizing RNA duplexes.

bioRxiv · Nov 10, 2022Biochemistry

In vitro evolution reveals primordial RNA-protein interaction mediated by metal cations

V. G. Giacobelli, K. Fujishima, M. Lepsik, V. Tretyachenko, T. Kadava, L. Bednarova, P. Novak, K. Hlouchova

This study uses in vitro evolution to show that RNA-protein interactions in early life could be mediated by metal cations and acidic residues instead of aromatic/basic amino acids.

bioRxiv · Aug 1, 2021 · PreprintBiochemistry

Enzyme catalysis prior to aromatic residues: reverse engineering of a dephosphoCoA kinase

M. Makarov, J. Meng, V. Tretyachenko, P. Srb, A. Brezinova, V. G. Giacobelli, L. Bednarova, J. Vondrasek, A. K. Dunker, K. Hlouchova

This study shows that enzyme catalysis can occur without aromatic amino acids by testing variants of dephosphoCoA kinase with reduced amino acid alphabets.

bioRxiv · Nov 11, 2020Biochemistry