Biased signaling downstream of epidermal growth factor receptor regulates proliferative versus apoptotic response to ligand
R. Ali, W. Brown, S. C. Purdy, V. J. Davisson, M. Wendt
This paper shows that in metastatic breast cancer, EGFR signaling is biased toward STAT1, leading to apoptosis, and that pharmacological biasing can enhance this effect.
bioRxiv · Jun 20, 2018Cancer Biology