Coordinate Enhancer Reprogramming by GATA3 and AP1 Promotes Phenotypic Plasticity to Achieve Breast Cancer Endocrine Resistance
M. Bi, Z. Zhang, H. Wang, P. Xue, K. Hernandez, X. Fu, C. De angelis, Z. Gao, J. Ruan, V. Jin, Q. Wang, E. Marangoni, T. H.-M. Huang, L. Chen, C. K. Glass, , Z. Liu
This study identifies GATA3 and AP1-driven enhancer reprogramming as a mechanism promoting phenotypic plasticity and endocrine resistance in breast cancer.
bioRxiv · Sep 16, 2019Cancer Biology