C. K. Glass

A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice

A prebiotic diet reduces motor deficits and microglial activation in α-synuclein overexpressing mice by altering gut microbiota and microglial states.

Systemic influences of mammary cancer on monocytes in mice

This study shows that mammary cancer in mice increases circulating and splenic monocytes without altering their ratios or half-lives, but changes their transcriptome, particularly in the bone marrow and blood, with differences from human breast cancer.

Monosodium Urate Crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response

This study shows that monosodium urate crystals induce a unique JNK-dependent metabolic and inflammatory response in macrophages, distinct from LPS, and that JNK inhibition reduces inflammation in gout models.

PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

The paper identifies PI3Kγ as a driver of microglia/macrophage accumulation in glioblastoma, showing its inhibition enhances temozolomide response in preclinical models.

The Human Milk Oligosaccharide 3-Sialyllactose Promotes Inflammation Resolution and Reduces Atherosclerosis Development in Mice.

This study shows that 3-sialyllactose reduces inflammation and atherosclerosis in mice by modulating transcriptional activity in macrophages.

Diet-regulated production of PDGFcc by macrophages controls energy storage

The paper identifies PDGFcc as a diet-regulated macrophage factor that controls energy storage in mammals by acting on adipocytes, independent of inflammation and insulin resistance.

Coordinate Enhancer Reprogramming by GATA3 and AP1 Promotes Phenotypic Plasticity to Achieve Breast Cancer Endocrine Resistance

This study identifies GATA3 and AP1-driven enhancer reprogramming as a mechanism promoting phenotypic plasticity and endocrine resistance in breast cancer.

PHLPP1 Counter-regulates STAT1-mediated Inflammatory Signaling

This paper identifies PHLPP1 as a phosphatase that dephosphorylates STAT1 to regulate inflammatory signaling in macrophages, with loss of PHLPP1 protecting mice from sepsis.

Engrafted parenchymal brain macrophages differ from host microglia in transcriptome, epigenome and response to challenge

This study compares transcriptomes, epigenomes, and responses to challenge between engrafted HSC-derived brain macrophages and host microglia, finding persistent molecular and functional differences.

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP pathways in macrophages

This study shows that desmosterol and its mimetics selectively activate LXR in macrophages without inducing SREBP1c-mediated hypertriglyceridemia, unlike conventional LXR agonists.