V. L. Bautch

Differential endothelial cell cycle status in postnatal retinal vessels revealed using a novel PIP-FUCCI reporter and zonation analysis

The paper introduces a novel PIP-FUCCI reporter to study endothelial cell cycle stages in postnatal retinal vessels and identifies G2 stalling in tip cells.

Endothelial cell flow-mediated quiescence is temporally regulated and utilizes the cell cycle inhibitor p27

This study shows that endothelial cell quiescence under flow is temporally regulated and depends on p27, with arterial flow leading to deeper quiescence requiring HES1 and ID3.

A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells

The paper identifies a clathrin-mediated trafficking pathway essential for sFLT1/VEGFR1 secretion from endothelial cells, revealing key components and their roles in vessel sprouting.

Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation

This study shows SUN1 stabilizes endothelial cell junctions via microtubules, regulating blood vessel formation and barrier function.

Single-Cell RNA Sequencing Reveals Endothelial Cell Transcriptome Heterogeneity under Homeostatic Laminar Flow

This study uses single-cell RNA sequencing to show that endothelial cells under laminar flow exhibit increased RNA heterogeneity but decreased protein heterogeneity.

Excess Centrosomes Disrupt Vascular Lumenization and Endothelial Cell Adherens Junctions

This study shows that excess centrosomes in endothelial cells disrupt apical-basal polarity and adherens junctions, leading to impaired lumen formation and reduced perfusion in zebrafish vessels.

SMAD6 Integrates Endothelial Cell Homeostatic Flow Responses Downstream of Notch

This study shows SMAD6 is essential for endothelial cell alignment under laminar shear flow, downstream of Notch1, and its loss disrupts barrier function and gene expression.