Pharmacologically targeting a novel pathway of sodium iodide symporter trafficking to enhance radioiodine uptake
A. Fletcher, M. L. Read, C. E. M. Thornton, D. P. Larner, V. L. Poole, K. Brookes, H. R. Nieto, M. Alshahrani, R. J. Thompson, G. G. Lavery, M. J. Campbell, K. Boelaert, A. S. Turnell, V. E. Smith, C. J. McCabe
This study identifies ARF4 and VCP as regulators of NIS trafficking and shows FDA-approved VCP inhibitors enhance radioiodine uptake in thyroid cancer cells and mice.
bioRxiv · May 7, 2019 · PreprintCancer Biology